Clinical Perspective
نویسندگان
چکیده
wnloaded DNA mismatch repair (MMR) system provides critical genetic housekeeping, and its failure is ased with tumorigenesis. Through distinct domains on the DNA MMR proteins, the system recognizes pairs errors occurring during DNA synthesis, but signals apoptosis when the DNA damage cannot aired. Certain missense mutations in the MMR genes can selectively alter just one of these functions. ffects the clinical features of tumors associated with defective DNA MMR activity. New work reThis a ported by Xie et al. in this issue of the journal (beginning on page 1409) adds to the understanding of DNA MMR. Cancer Prev Res; 3(11); 1371–4. ©2010 AACR.
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